Peptide

Palmitoyl Tripeptide-5

SYN-COLL — a peptide activator of TGF-β that initiates natural collagen synthesis from within. Palmitoyl tripeptide-5 mimics thrombospondin-1 and activates the skin's own collagenogenesis without introducing collagen from outside. One of the most effective peptides against sagging and wrinkles.

SYN-COLLTGF-βcollagenanti-aging

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Palmitoyl Tripeptide-5 — palmitoyl ester of the tripeptide Lys-Val-Lys (or KVK). Trade name SYN-COLL® (DSM). The mechanism is unique: the peptide mimics the domain of thrombospondin-1 — an extracellular protein that activates latent TGF-β1. TGF-β1 is a powerful stimulator of collagen I, II, and III synthesis in fibroblasts. Thus, the peptide 'turns on' the natural collagenogenesis cascade rather than simply supplying amino acids.

Premium anti-aging serums and lifting creams. Effective concentration from 1–3 ppm. Works well with other peptides (Matrixyl, adenosine) and antioxidants.

Key Benefits

✦

Activation of TGF-β and natural collagenogenesis

Unique mechanism through thrombospondin-1 mimetism: activates TGF-β1 — the main regulator of collagen synthesis in the dermis. Clinical data from DSM: increase in procollagen I by 119% and decrease in MMP-1 (collagenase) by 27% in vitro. The effect differs from matrikines in that a higher-level signaling pathway is involved.

◈

Lifting and increased skin density

In vivo study of SYN-COLL: 12 weeks of 2% peptide cream — reduction of wrinkle depth by 11.4%, increase in firmness by 20%, improvement in skin smoothness. The lifting effect is noticeable with regular use due to the accumulation of new collagen in the dermis.

✧

Reduction of MMP activity — protection of existing collagen

Along with stimulating synthesis — inhibition of matrix metalloproteinases that break down collagen. Dual action: more new + less old is broken down. Especially valuable in photoaging, where MMPs are excessively activated by UV radiation.

Suitable for

mature skinskin with reduced elasticitynormal skin

Main Actions

✓ activation of collagen synthesis through TGF-β✓ lifting and firmness✓ protection from collagen degradation

SYN-COLL vs Matrixyl

Matrixyl (palmitoyl pentapeptide-4) — a matrikine: a fragment of collagen that signals damage. SYN-COLL (palmitoyl tripeptide-5) — a TGF-β activator: initiates a higher signaling cascade. Different mechanisms, but both stimulate collagen. The combination of two approaches in one formula — synergy.

CategoryPeptides

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