Peptide

Palmitoyl Tripeptide-1

The key component Matrixyl 3000 — palmitoyl tripeptide-1 in combination with palmitoyl tetrapeptide-7 forms the most researched peptide duo for collagen matrix restoration. Clinically proven: Matrixyl 3000 stimulates collagen synthesis more effectively than most monopeptides.

Matrixyl 3000collagenanti-agingmatrix

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Palmitoyl Tripeptide-1 (PAL-GHK) — a palmitoyl ester of the tripeptide Gly-His-Lys. GHK — a natural peptide from human blood that signals tissue damage and initiates regeneration. The palmitoyl group enhances penetration. Together with Palmitoyl Tetrapeptide-7 (PAL-GQPR), it forms the patented Matrixyl 3000® blend (Sederma). GQPR — an anti-inflammatory peptide that reduces IL-6. Together, they affect matrix synthesis and inflammation simultaneously.

A premium anti-aging component in combination with palmitoyl tetrapeptide-7. Effective in serums and creams for mature skin. The effective concentration starts from 3 ppm (0.0003%) — powerful in small doses.

Key Benefits

✦

Stimulation of collagen I, III, and hyaluronic acid

PAL-GHK (tripeptide-1) activates the synthesis of procollagen I and III, fibronectin, and HA in fibroblasts. GHK-copper (CuGHK) — a natural analogue — is one of the most powerful collagen stimulators. The palmitoyl form reaches fibroblasts through the stratum corneum without the copper ion.

◈

Matrixyl 3000: synergy of two peptides

The combination of PAL-GHK + PAL-GQPR (tetrapeptide-7) acts synergistically: tripeptide-1 stimulates the matrix, tetrapeptide-7 reduces inflammation. Sederma ex vivo studies: +18% collagen III, +27% laminin-5, +30% HA. Clinical in vivo data: 45% reduction in wrinkle depth over 2 months.

✧

Reduction of inflammation through Tetrapeptide-7

Palmitoyl Tetrapeptide-7 (GQPR) lowers IL-6 levels — a marker of chronic dermal inflammation. Inflammaging is a key mechanism of skin aging. The anti-inflammatory action of Matrixyl 3000 distinguishes it from purely stimulating peptides.

Suitable for

mature skinwrinkled skinnormal skin

Main Actions

✓ stimulation of collagen and matrix✓ Matrixyl 3000 effect✓ reduction of inflammation

Matrixyl vs Matrixyl 3000

Matrixyl (original) = Palmitoyl Pentapeptide-4 (KTTKS). Matrixyl 3000 = Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7. The next generation targets more pathways: not only collagen synthesis but also inflammation and laminin. A better choice for comprehensive anti-aging. Some products contain both generations.

CategoryPeptides

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