Peptide

Palmitoyl Hexapeptide-12

Leuphasyl — antagonist of painful receptors at the neuromuscular junction. It blocks the contraction of mimic muscles, reducing the depth of wrinkles without injections. It potentiates the action of Argireline (acetyl hexapeptide-3) by 2 times.

Leuphasylneuropeptideanti-wrinklebotox-like

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Palmitoyl Hexapeptide-12 — palmitoyl ester of hexapeptide (sequence TSLLDN). Trade name Leuphasyl® (Lipotec/Lubrizol). Mechanism of action: analogue of enk-peptide (enkephalin-like), modulating the release of acetylcholine at the neuromuscular junction. Unlike Argireline (which blocks the SNARE complex), Leuphasyl acts through opioid receptors — a different, complementary mechanism. Effective concentration: 4–5 ppm.

Anti-aging formulas for mimic zones (forehead, periorbital area, nasolabial folds). Most effective in combination with acetyl hexapeptide-3 (Argireline) or Leuphasyl-Argireline blend.

Key Benefits

✦

Relaxation of mimic muscles — a mechanism different from Argireline

Palmitoyl Hexapeptide-12 acts through μ-opioid receptors, modulating neurotransmission at the neuromuscular junction. It reduces the level of acetylcholine release → weaker mimic contraction → less depth of dynamic wrinkles. The mechanism is complementary to Argireline (SNARE-blocking), so the combination of the two peptides provides a synergistic effect.

◈

Synergy with Argireline — doubled effect

Clinical studies by Lipotec: Leuphasyl (4 ppm) + Argireline (4 ppm) — reduction of wrinkles around the eyes by 23% compared to 11% for each separately. Thus, the combination is more than 2 times more effective than each peptide alone. That is why most quality "botox-like" formulas contain both peptides simultaneously.

✧

Softness and safety with prolonged use

Does not cause muscle immobilization (unlike botulinum toxin) — the effect is reversible and partial. Does not disrupt neuromuscular function overall. Safe for sensitive skin, does not cause habituation. The effect accumulates with regular use.

Suitable for

mature skinskin with mimic wrinklesall skin types

Main Actions

✓ relaxation of mimic muscles✓ reduction of wrinkles (synergy with Argireline)✓ neuromodulation

Trio of neuropeptides

Argireline (acetyl hexapeptide-3) — blocks SNARE, reduces the release of mediators. Leuphasyl (palmitoyl hexapeptide-12) — μ-opioid modulation, reduces acetylcholine. SNAP-8 (acetyl octapeptide-3) — an extended version of Argireline, a larger molecule. All three — different mechanisms of blocking neurotransmission. For maximum effect: Argireline + Leuphasyl (minimum), SNAP-8 can be added.

CategoryPeptides

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