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Inositol

Vitamin-like molecule of cellular signaling — inositol regulates sebum production, moisturizes, and supports the microbiome. Naturally found in all body cells and present in the plant world.

Sebum regulationHydrationB8Cellular signaling

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Inositol (myo-inositol) — a cyclic polyol (C₆H₁₂O₆), structurally related to glucose. Previously classified as vitamin B8 (pseudo-vitamin, synthesized by the body). Present in all cells as phosphatidylinositol (PIP, PIP₂, PIP₃) — key secondary messengers in insulin signaling and cell growth. In cosmetics: moisturizer, sebum regulator, microbiome support. Natural sources: fruits (melon, orange), legumes, nuts.

Moisturizing and sebum-regulating formulas. Interesting for oily and combination skin. Combines with niacinamide and zinc PCA for sebum control.

Key Benefits

✦

Regulation of sebum production through insulin signaling: Inositol modulates the signaling pathway of insulin-like growth factor (IGF-1) in sebaceous glands. Increased IGF-1 stimulates excessive sebum production in acne. Inositol reduces the sensitivity of sebaceous glands to IGF-1, normalizing sebum production. The effect is milder than that of retinoids, but without irritation.

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Hydration of the stratum corneum: Hygroscopic OH groups of inositol attract water and retain it in the stratum corneum. Forms a protective film, reducing TEWL. An effective moisturizer in toners and light essences — pleasant texture without a sticky feeling.

✧

Support for the microbiome and prebiotic effect: Inositol is a substrate for some beneficial bacteria of the skin microbiome — prebiotic effect. Supports pH and conditions for normal microflora. In combination with postbiotics (lactobacillus, bifida) — synergy for microbiome balance.

Suitable for

Oily skinCombination skinNormal skin

Main Actions

✓ Sebum regulation✓ Hydration✓ Microbiome support

Inositol and acne

Inositol is being studied in PCOS (polycystic ovary syndrome) — a condition associated with acne and hyperseborrhea due to hyperinsulinemia. Oral myo-inositol in PCOS significantly reduces acne. Topical inositol — a milder effect, but a useful complementary component in acne products without irritation.

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