Antioxidant

Hydroxyresveratrol

The most active form of resveratrol — hydroxyresveratrol (oxyresveratrol) is dozens of times more powerful than regular resveratrol as a tyrosinase inhibitor. A natural component of mulberry and plant roots with powerful antioxidant and brightening properties.

AntioxidantBrighteningTyrosinaseMulberry

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Hydroxyresveratrol (also known as oxyresveratrol or trans-oxyresveratrol) — a natural stilbenoid found in the bark and roots of Morus alba (white mulberry), Artocarpus lakoocha, and other plants. Structurally similar to resveratrol, but with an additional hydroxyl group that dramatically increases its biological activity. Comparative efficacy studies: hydroxyresveratrol inhibits tyrosinase 32–40 times more strongly than resveratrol and 10–15 times more strongly than kojic acid in in vitro conditions. Mechanisms: tyrosinase inhibition (competitive), antioxidant activity through free radical neutralization, anti-inflammatory effect through NF-κB inhibition.

Serums and creams for pigmentation correction. Effective in combination with vitamin C, niacinamide, or arbutin. Concentration 0.5–3%. More stable than resveratrol due to structural features. May be listed as 'mulberry extract' or 'Morus alba root extract' in INCI.

Key Benefits

✦

Super powerful tyrosinase inhibition

In vitro data show 32–40 times the activity over resveratrol and 10–15 times over kojic acid. Competitive mechanism of tyrosinase inhibition: hydroxyresveratrol occupies the catalytic center of the enzyme, blocking the conversion of tyrosine to DOPA and further to melanin. Clinical studies with mulberry extract show comparable efficacy to 4% hydroquinone in reducing melasma with a better safety profile.

◈

Antioxidant protection and photoprotection

High antioxidant activity through several mechanisms: neutralization of ROS (free radicals), metal chelation, and inhibition of lipid peroxidation. Protects keratinocyte DNA from UVB-induced damage. The anti-inflammatory action synergizes with the brightening effect: by reducing UV-induced inflammation, it lowers pigmentation triggers.

Suitable for

Skin with pigmentationSkin with melasmaNormal and combination skin

Main Actions

✓ Tyrosinase inhibition✓ Antioxidant protection

Mulberry extract and hydroxyresveratrol

Most products with 'mulberry extract' or 'Morus alba extract' contain hydroxyresveratrol as an active component, but are not always standardized for its content. For maximum effect, look for products with 'oxyresveratrol' or 'hydroxyresveratrol' in INCI — this means a purified molecule with known concentration is used, rather than an unstandardized plant extract.

CategoryAntioxidants

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