Soothing

Asiaticoside

One of the four key active ingredients of Centella asiatica — asiaticoside stimulates collagen synthesis through a unique mechanism of activating the antimicrobial peptide LL-37, accelerates wound healing, and enhances the effect of madecassoside in skin recovery.

CentellaCollagenRecoveryHealing

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Asiaticoside — a triterpenoid saponin isolated from Centella asiatica. One of the four main actives of Centella along with madecassoside, asiatic acid, and madecassic acid. Unlike madecassoside (which inhibits inflammation via NF-κB), asiaticoside acts primarily through the stimulation of the antimicrobial peptide LL-37 synthesis in keratinocytes. LL-37 is a catalyst for collagen synthesis via a TGF-β1-independent pathway. Additionally: asiaticoside is hydrolyzed in the skin to asiatic acid, which directly activates fibroblast proliferation. Clinically used in the Madecassol preparation for the treatment of wounds, burns, and scars — often in combination with madecassoside.

Products for recovery after procedures, scar treatment, soothing reactive skin. Synergistically used together with madecassoside, panthenol, and ceramides. Concentration 0.1–1% in combination with other actives of Centella. Predominantly found in standardized CICA formulas.

Key Benefits

✦

Stimulation of collagen through LL-37

Asiaticoside induces the synthesis of the antimicrobial peptide LL-37 in keratinocytes. LL-37 activates EGF (epidermal growth factor) receptors and initiates a cascade of collagen type I and III synthesis through a TGF-β1-independent pathway. This mechanism is complementary to madecassoside (which acts through TGF-β1), explaining the powerful effect of combining both molecules in CICA formulas.

◈

Wound healing and scar reduction

Clinical data confirm the effectiveness of asiaticoside in treating second-degree wounds, surgical incisions, and hypertrophic scars. The Madecassol preparation (asiaticoside + madecassic acid + asiatic acid) is used in medicine for the treatment of chronic wounds and burns. In vitro: accelerates keratinocyte migration and fibroblast proliferation, which are key stages of healing.

Suitable for

Sensitive and reactive skinSkin after proceduresSkin prone to scarring

Main Actions

✓ Stimulation of collagen synthesis✓ Acceleration of healing

CICA formulas: a combination of Centella actives

Most modern CICA products contain a combination of several Centella actives: madecassoside + asiaticoside + asiatic acid + madecassic acid. Together they provide a synergistic effect through various mechanisms (NF-κB, TGF-β1, LL-37, EGF). The standardized extract TECA (Titrated Extract of Centella Asiatica) contains 40% asiaticoside, 29–30% asiatic acid, 29–30% madecassic acid, and 1% madecassoside — the gold standard of clinical research.

CategorySoothing Ingredients

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