Emollient

Acetyl Dipeptide-1 Cetyl Ester

Calmosensine — a peptide against skin stress and fatigue. It blocks pain and stress receptors (CGRP pathway), reducing chronic inflammation from neurogenic stress. It restores a "calm" appearance to the skin after exhaustion and chronic stress.

Calmosensineanti-stressneuropeptideCGRP

✓ Safe

Comedogenic Rating

0/5

Irritation Potential

0/5

What is it?

Acetyl Dipeptide-1 Cetyl Ester — cetyl ester of acetylated dipeptide (Ac-Tyr-Arg-OC16). Trade name Calmosensine® (Sederma). Mechanism: antagonist or modulator of CGRP receptors in the skin. CGRP — a neuropeptide released during stress and pain → neurogenic inflammation, redness, increased skin sensitivity. Calmosensine blocks this signaling pathway. Effective concentration: 0.5–1%. INCI: Acetyl Dipeptide-1 Cetyl Ester.

Products for sensitive skin, anti-stress formulas, products to improve the "rested" appearance of the skin. Especially relevant in combination with night creams and masks.

Key Benefits

✦

Reduction of neurogenic inflammation — the "calming" mechanism

Stress, lack of sleep, and pollution activate the CGRP pathway in the skin — neurogenic inflammation without visible external cause. Result: increased reactivity, redness, tightness. Calmosensine blocks CGRP receptors → reduces neurogenic inflammation → skin becomes less reactive and calmer. The effect is noticeable after just 2–4 weeks of regular use.

◈

Restoration of the "rested" skin appearance

Sederma study: 1% Calmosensine vs placebo — significant improvement in the appearance of "exhausted, stressed skin." Evaluators noted: less dull tone, less visible fatigue, more lifted appearance. Mechanism — reduction of chronic neuroinflammation that suppresses normal cell function.

✧

Synergy with other soothing components

Calmosensine (CGRP blockade) + bissabolol (inflammation) + panthenol (restoration) + ectoin (osmoprotection) = complete anti-stress complex. Especially effective in night products, where the skin recovers from daily stress. Well combined with adaptogens (ashwagandha, rhodiola) in next-generation formulas.

Suitable for

sensitive skinreactive skinskin prone to rednessskin in stress

Main Actions

✓ reduction of neurogenic inflammation✓ calming of reactive skin✓ restoration of appearance

Neurocosmetics — a new direction

Neurocosmetics (neurocosmetics) — products that affect neural transmission in the skin. The nervous system of the skin plays a huge role in its reactions and aging. Calmosensine is the first widely known neuropeptide of this class. Along with Argireline (neuromuscular block) and Leuphasyl (opioid modulation) — a new wave of cosmetic peptides acting through neural mechanisms.

CategoryEmollients

Check if this ingredient works for your skin — analyze your full product formula for free.

Analyze your product